General News

San Diego, California and Vancouver, British Columbia, November 30, 2012 – Sophiris Bio, Inc. (TSX: SHS) today announced the appointment of Noah Knauf as a director of the Company. Mr. Knauf replaces Jonathan Leff, who has resigned as a director, as a Warburg Pincus nominee director.

Mr. Knauf focuses on healthcare and life sciences as an investment professional at Warburg Pincus. He currently serves on the Boards of Directors of Constitution Medical Investors, Home Dialysis Plus, International Technidyne Corporation, Keystone Dental, RegionalCare Hospital Partners and Silk Road Medical. Prior to joining Warburg Pincus, Mr. Knauf was an Associate at Parthenon Capital, a private equity firm, and a consultant with Bain & Company, a global consulting firm. He holds an MBA from Stanford University Graduate School of Business where he was an Arjay Miller Scholar, and earned a Bachelor of Science in Business Administration degree (BSBA) from the University of Arizona.
Sophiris Bio would like to thank Jonathan Leff for his service to the board and to the Company.

About Sophiris

Sophiris Bio Inc. is a urology company developing a late-stage, highly targeted treatment for benign prostatic hyperplasia (BPH or enlarged prostate), an unsatisfied market with significant demand. PRX302, the company’s lead candidate for BPH, is designed to be as efficacious as pharmaceuticals, less invasive than the surgical interventions, and without the sexual side effects seen with existing treatments. Sophiris is planning to begin a pivotal trial in the first half of 2013. Sophiris is advised by world-leading urologists, backed by experienced investors, and led by a team that has achieved more than twenty drug approvals. For more information, please visit www.sophirisbio.com.

Certain statements included in this press release may be considered forward-looking. Such statements involve known and unknown risks, uncertainties and other factors that may cause actual results, performance or achievements to be materially different from those implied by such statements, and therefore these statements should not be read as guarantees of future performance or results. All forward-looking statements are based on Sophiris’ current beliefs as well as assumptions made by and information currently available to Sophiris and relate to, among other things, anticipated financial performance, business prospects, strategies, regulatory developments, market acceptance and future commitments. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release. Due to risks and uncertainties, including the risks and uncertainties identified by Sophiris in its public securities filings; actual events may differ materially from current expectations. Sophiris disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

For further information contact:

Lauren Glaser
Investor Relations
The Trout Group
646-378-2972
lglaser@troutgroup.com

James Beesley
Investor Relations
Sequoia Partners
778-389-7715
james@sequoiapartners.ca

Michael Moore
Investor Relations
Equicom Group
619-467-7067
mmore@equicomgroup.com

Jason I. Spark
Canale Communications, Inc.
619-849-6005
jason@canalecomm.com

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